Chaudhuri Anjana Ray, Chatterjee Siddhartha
Calcutta Fertility Mission, Kolkata, India.
J Basic Clin Physiol Pharmacol. 2013;24(2):125-30. doi: 10.1515/jbcpp-2012-0052.
With the success of oocyte donation in vitro fertilization (IVF) in postmenopausal women, the importance of endometrial preparation became obvious. This appears also very crucial for achieving pregnancy after frozen embryo transfer (FET) after failed fresh IVF cycles and FET in subsequent natural cycles. Although there are different methods of preparing endometrium, in this study, another method of preparing the implantation bed using letrozole was scrutinized for its usefulness.
Two hundred and seventy patients between 28 and 40 years of age undergoing IVF due to bilateral tubal blocks were chosen for FET. They had a previous unsuccessful single IVF attempt or had postponed embryo transfer due to the threat of ovarian hyperstimulation syndrome or poor endometrial development. Informed consents were obtained from the participants. One hundred patients had endometrial preparation by gonadotrophin-releasing hormone agonist down-regulation and with hormone replacement therapy, 55 had natural cycle FET, and the remaining 115 patients had letrozole-induced ovulation induction (OI) for endometrial preparation.
The clinical and biochemical pregnancy rate or live birth rate was higher in the letrozole OI group than in the other two groups.
OI by letrozole and subsequent endometrial preparation as a result of it may be utilized for FET, and this will be cheap and easy to administer, giving better success rates in FET cycles.
随着绝经后妇女卵母细胞捐赠体外受精（IVF）的成功，子宫内膜准备的重要性变得明显。这对于在新鲜IVF周期失败后进行冷冻胚胎移植（FET）以及随后自然周期的FET后实现妊娠似乎也非常关键。尽管有不同的子宫内膜准备方法，但在本研究中，对另一种使用来曲唑准备着床床的方法的实用性进行了仔细研究。
选择270例年龄在28至40岁之间因双侧输卵管阻塞而接受IVF的患者进行FET。他们之前有过一次IVF尝试失败，或者因卵巢过度刺激综合征的威胁或子宫内膜发育不良而推迟了胚胎移植。从参与者那里获得了知情同意书。100例患者通过促性腺激素释放激素激动剂下调并进行激素替代疗法进行子宫内膜准备，55例进行自然周期FET，其余115例患者使用来曲唑诱导排卵（OI）进行子宫内膜准备。
来曲唑OI组的临床和生化妊娠率或活产率高于其他两组。
来曲唑诱导排卵及其后的子宫内膜准备可用于FET，这将便宜且易于实施，在FET周期中成功率更高。
