ESRC Innogen Centre, University of Edinburgh, United Kingdom.
Drug Discov Today. 2013 May;18(9-10):420-7. doi: 10.1016/j.drudis.2013.01.004. Epub 2013 Jan 19.
This article suggests that successful innovation in biopharmaceuticals is strongly related to the ability of firms to move compounds forward along the drug pipeline, relatively to other companies, within the same therapeutic area. We used this intuition to build indicators of performance at the firm-level and use them to conduct empirical analysis that relies upon a comprehensive database. We consider the effect of various factors on drug development performance, including R&D funds allocation across therapeutic areas and the proportion of biological molecules in the drug development portfolio. Subsequently, we show that a correlation exists between our performance variables and the per-capita growth of biopharmaceutical firms' revenues.
本文认为,在同一治疗领域内,企业相对于其他公司将化合物沿着药物研发管线推进的能力与生物制药的成功创新密切相关。我们利用这种直觉构建了企业层面的绩效指标,并利用这些指标进行了实证分析,该分析依赖于一个全面的数据库。我们考虑了各种因素对药物开发绩效的影响,包括跨治疗领域的研发资金分配和药物开发组合中生物分子的比例。随后,我们表明,我们的绩效变量与生物制药公司收入的人均增长率之间存在相关性。