Institut de Recerca Contra la Leucèmia Josep Carreras, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Leuk Res. 2013 Apr;37(4):416-21. doi: 10.1016/j.leukres.2012.12.010. Epub 2013 Jan 18.
Chromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.
在新发骨髓增生异常综合征（MDS）患者中，有 40%-60%的患者可检测到染色体异常。本研究对 773 例未经常规 G 显带细胞遗传学（CC）证实存在单体 7（-7）或 7q 缺失（7q-）的新发 MDS 患者使用 FISH 技术进行检测，单独通过 FISH 分析其预后影响。FISH 检测到 5.2%的患者存在-7/7q-。与不存在这些异常的患者相比，存在-7/7q-与总生存期更短相关。我们的结果表明，对于形态学危险分层为中危的患者，且 CC 未发现-7/7q-的患者，FISH 7q 可能是有益的。
