Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1052, USA.
Biochem Biophys Res Commun. 2013 Feb 22;431(4):647-51. doi: 10.1016/j.bbrc.2013.01.041. Epub 2013 Jan 19.
Tumor resistance to cytotoxic therapeutics coupled with dose-limiting toxicity is a serious hurdle in the field of medical oncology. In the face of this obstacle, nitric oxide has emerged as a powerful adjuvant for the hypersensitization of tumors to more traditional chemo- and radio-therapeutics. Furthermore, emerging evidence indicates that nitric oxide donors have the potential to function independently in the clinical management of cancer. Herein, we discuss the role of nitric oxide in cancer and the potential for nitric oxide donors to support conventional therapeutics.
肿瘤对细胞毒性治疗的耐药性加上剂量限制毒性是医学肿瘤学领域的一个严重障碍。面对这一障碍，一氧化氮已成为使肿瘤对更传统的化疗和放疗产生超敏作用的有力辅助剂。此外，新出现的证据表明，一氧化氮供体有可能在癌症的临床治疗中独立发挥作用。本文讨论了一氧化氮在癌症中的作用以及一氧化氮供体支持传统治疗的潜力。
