Heim J
J Gynecol Obstet Biol Reprod (Paris). 1979;8(8):745-9.
A synthesis has been attempted to explain the metabolic action of oestrogen-progestogens: and their action on carbohydrates, triglycerides, cholesterol, lipoproteins and coagulation has been reviewed. Carbohydrate tolerance can evolve in different ways, depending on the case. On the one hand hyperglycaemia, which is provoked by taking carbohydrates by mouth in a primitively pathological way, can be improved while on the other hand there can be diminution in carbohydrate tolerance in other cases. Two factors, however, remain constant, hyperinsulinism and resistance to insulin. There is no way of predicting how carbohydrate tolerance will behave. That is why pills that contain oestrogens and progestogens, even if they are "mini-dose" pills, are contra-indicated for women who have pancreatic diabetes. Pills with a high oestrogen content raise the triglycerides, while those which have a higher progestogen content tend to raise the blood cholesterol levels. High-density lipoprotein tends to be raised with an oestrogenic milieu and lowered with progestogens or with pills that have a strong progestogen content.
人们尝试进行了一项综合研究来解释雌激素 - 孕激素的代谢作用，并对它们在碳水化合物、甘油三酯、胆固醇、脂蛋白及凝血方面的作用进行了综述。碳水化合物耐受性会因情况而异，有不同的变化方式。一方面，以原始病理方式口服碳水化合物引发的高血糖症可能会得到改善；另一方面，在其他情况下碳水化合物耐受性可能会降低。然而，有两个因素保持不变，即高胰岛素血症和胰岛素抵抗。无法预测碳水化合物耐受性会如何变化。这就是为什么即使是“小剂量”的含雌激素和孕激素的药丸，对于患有胰腺性糖尿病的女性也是禁忌的。高雌激素含量的药丸会使甘油三酯升高，而孕激素含量较高的药丸往往会使血液胆固醇水平升高。在雌激素环境下高密度脂蛋白往往会升高，而在孕激素或孕激素含量高的药丸作用下则会降低。
