Nogami Tomohiro, Shien Tadahiko, Tanaka Takehiro, Doihara Hiroyoshi, Taira Naruto, Takabatake Daisuke, Nishimura Rieko, Nishiyama Keiko, Mizoo Taeko, Ohsumi Shozo
Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan,
Breast Cancer. 2014 Nov;21(6):698-702. doi: 10.1007/s12282-013-0445-7. Epub 2013 Jan 22.
We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.
We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.
None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.
There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.
我们评估了乳腺癌患者原发性乳腺病变与肺转移（PM）病变之间醛脱氢酶1（ALDH1）的表达情况。
我们回顾性分析了原发性和转移性乳腺癌病变的临床病理特征以及雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）、Ki-67和ALDH-1的表达状态，评估了这些标志物在原发性和转移性病变之间表达的不一致率，以及这些因素的预后价值。
所有PM患者均无其他部位转移，且均接受了乳腺癌根治性手术。15例（88%）患者接受了肺部分切除术，2例（12%）患者接受了肺叶切除术。切除PM后中位总生存期（OS）为48个月。原发性和转移性病变之间ER、PR、HER2、Ki67和ALDH-1表达的不一致率分别为0%、29%、21%、43%和50%。
原发性肿瘤与转移性病变之间的生物标志物存在显著差异。
