Department of Microbiology, Government Medical College Hospital, Chandigarh, India.
Asian Pac J Trop Med. 2013 Feb;6(2):167-8. doi: 10.1016/S1995-7645(13)60017-6.
Outbreaks of enteric fever are a major health concern not only due to significant human morbidity and mortality but also fear of spread of multidrug resistant strains. We report an outbreak of enteric fever caused by Salmonella enterica serotype Typhi in a suburban area, in city Chandigarh of North India. Twenty-seven strains of S. typhi were isolated from blood cultures over a period of two weeks with 18 of these 27 patients residing in the same area. Maximum cases were in the age group 5-14 years (10 patients, 55.5%) while 4 (22.2%) cases were children under 5 years. All the strains showed similar resistogram being resistant to ampicillin and nalidixic acid, intermediate to ciprofloxacin and sensitive to chloramphenicol, ceftriaxone, cefotaxime, cotrimoxazole and azithromycin on disc diffusion testing. Minimum inhibitory concentration of ciprofloxacin was determined by agar dilution method and was found to be raised (≥ 2 μ g/mL). This nalidixic acid resistant S. typhi outbreak report warrants the necessity of implementing stringent sanitation practices in public health interest.
肠热病的爆发不仅对人类的发病率和死亡率有重大影响，而且还会引起人们对多药耐药株传播的担忧，因此是一个主要的健康问题。我们报告了一起在印度北部城市昌迪加尔郊区发生的伤寒沙门氏菌肠热病爆发。在两周的时间里，从血液培养物中分离出 27 株伤寒沙门氏菌，其中 18 例患者居住在同一地区。最大的病例发生在 5-14 岁年龄组（10 例，55.5%），而 4 例（22.2%）为 5 岁以下儿童。所有菌株的耐药谱相似，对氨苄西林和萘啶酸耐药，对环丙沙星中介，对氯霉素、头孢曲松、头孢噻肟、复方磺胺甲噁唑和阿奇霉素敏感。通过琼脂稀释法测定环丙沙星的最低抑菌浓度，发现其升高（≥2μg/ml）。这次萘啶酸耐药伤寒沙门氏菌的爆发报告证明，为了公众健康利益，有必要实施严格的卫生措施。
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