Rathish K C, Chandrashekar M R, Nagesha C N
Department of Microbiology, Dr. B.R. Ambedkar Medical College, Bangalore.
Indian J Pediatr. 1995 Jul-Aug;62(4):445-8. doi: 10.1007/BF02755065.
Six hundred and eighty five blood cultures from children clinically diagnosed as enteric fever yielded 176 salmonella strains showing isolation success rate of 25.7%, S. typhi were 164 (93.2%), S. paratyphi A 5 (2.8%), S. choleraesuis 4 (2.3%) and S. typhimurium 3 (1.7%). Antibiogram of 164 isolates of S. typhi showed triple drug resistance (TDR) in 156 strains (95.1%) to chloramphenicol, ampicillin and cotrimoxazole, and sensitivity of 90.2% and 95.1% to norfloxacin and ciprofloxacin respectively. Minimum inhibitory concentrations (MIC) of chloramphenicol were between 360 mcg and 640 mcg per ml. Phage types of 38 strains of TDR S. typhi were predominantly E1 and 0 with prevalences of 47.4% and 36.8% respectively in this region. All children with S. typhi isolates sensitive to quinolones in Vitro responded well to these drugs with almost no relapse and hence, the newer generation of quinolones could be considered as the first choice in the primary treatment of enteric fever.
对685份临床诊断为伤寒的儿童血培养样本进行检测，分离出176株沙门氏菌，分离成功率为25.7%，其中伤寒杆菌164株（93.2%），甲型副伤寒杆菌5株（2.8%），猪霍乱沙门氏菌4株（2.3%），鼠伤寒沙门氏菌3株（1.7%）。对164株伤寒杆菌进行药敏试验，结果显示156株（95.1%）对氯霉素、氨苄西林和复方新诺明呈现三重耐药（TDR），对诺氟沙星和环丙沙星的敏感性分别为90.2%和95.1%。氯霉素的最低抑菌浓度（MIC）在每毫升360微克至640微克之间。该地区38株TDR伤寒杆菌的噬菌体类型主要为E1型和0型，患病率分别为47.4%和36.8%。所有体外对喹诺酮类药物敏感的伤寒杆菌分离株患儿对这些药物反应良好，几乎无复发情况，因此，新一代喹诺酮类药物可被视为伤寒一线治疗的首选药物。
