Gambari R, Barbieri R, Feriotto G, Spandidos D, Nastruzzi C
Istituto di Chimica Biologica, Università di Ferrara, Italy.
Anticancer Res. 1990 Jan-Feb;10(1):259-63.
Some of the biological processes which enhance the metastatic capacity of tumor cells are associated with the activation of proteinases. In this paper we examined the effects of aromatic polyamidines on "in vitro" invasiveness of tumor cell lines. In addition to their antiproteinase activity, aromatic polyamidines exhibit antiproliferative activity toward tumor cell lines and inhibit expression of specific oncogenes. The results obtained show that the aromatic polyamidine TAPP-Br does not affect attachment, but inhibits the "in vitro" invasiveness of tumor cells cultured on a reconstituted basement membrane composed by laminin, type IV collagen, entactin, heparan sulphate proteoglycans. Our data suggest that this and related compounds should be further studied as experimental antitumor agents.
一些增强肿瘤细胞转移能力的生物学过程与蛋白酶的激活有关。在本文中，我们研究了芳香族聚脒对肿瘤细胞系“体外”侵袭能力的影响。除了具有抗蛋白酶活性外，芳香族聚脒还对肿瘤细胞系表现出抗增殖活性，并抑制特定癌基因的表达。所得结果表明，芳香族聚脒TAPP-Br不影响肿瘤细胞的黏附，但能抑制在由层粘连蛋白、IV型胶原、巢蛋白、硫酸乙酰肝素蛋白聚糖组成的重组基底膜上培养的肿瘤细胞的“体外”侵袭能力。我们的数据表明，这种及相关化合物应作为实验性抗肿瘤药物进行进一步研究。
