早发性痴呆患者身体功能的纵向研究。
A longitudinal study of physical function in patients with early-onset dementia.
作者信息
Tangen Gro Gujord, Londos Elisabet, Olsson Johan, Minthon Lennart, Mengshoel Anne Marit
机构信息
Department of Health Sciences, University of Oslo, Oslo, Norway.
出版信息
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):622-31. doi: 10.1159/000345782. Epub 2012 Dec 13.
BACKGROUND
The aim of this study was to explore changes in mobility in terms of ambulation and transfer over 1 year in patients with early-onset Alzheimer's disease (EOAD), and to compare mobility in EOAD with patients with other types of early-onset dementia (EOOD).
METHOD
Forty-two patients with EOAD and 30 patients with EOOD were included. All patients were home-dwelling and had mild or moderate degree of dementia. Mobility was assessed using the Timed Up and Go Test (TUG), a modified version of the Clinical Outcome Variables Scale, timed stair walking, and timed rise from the floor.
RESULTS
The EOAD group performed significantly better than the EOOD group on all mobility tests. After 1 year, 25 persons with EOAD were tested again. The performance on TUG (p = 0.028) and stair walking (p = 0.02) had deteriorated at the 1-year follow-up in the EOAD group.
CONCLUSION
Patients with EOAD performed better on mobility tasks than patients with EOOD, but their performance deteriorated at 1-year follow-up.
背景
本研究的目的是探讨早发性阿尔茨海默病（EOAD）患者在1年时间里行走和转移方面的活动能力变化，并将EOAD患者的活动能力与其他类型早发性痴呆（EOOD）患者进行比较。
方法
纳入42例EOAD患者和30例EOOD患者。所有患者均居家生活，患有轻度或中度痴呆。使用定时起立行走测试（TUG）、临床结局变量量表的修订版、定时上下楼梯行走测试以及从地面定时起立测试对活动能力进行评估。
结果
在所有活动能力测试中，EOAD组的表现均显著优于EOOD组。1年后，对25例EOAD患者再次进行测试。在1年随访时，EOAD组在TUG测试（p = 0.028）和上下楼梯行走测试（p = 0.02）中的表现有所恶化。
结论
EOAD患者在活动任务中的表现优于EOOD患者，但在1年随访时其表现有所恶化。
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