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Five times sit to stand test is a predictor of recurrent falls in healthy community-living subjects aged 65 and older.五次坐立试验是65岁及以上健康社区居住受试者反复跌倒的一个预测指标。
J Am Geriatr Soc. 2008 Aug;56(8):1575-7. doi: 10.1111/j.1532-5415.2008.01777.x.
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Trail Making Test errors in normal aging, mild cognitive impairment, and dementia.正常衰老、轻度认知障碍和痴呆中的连线测验错误
Arch Clin Neuropsychol. 2008 Mar;23(2):129-37. doi: 10.1016/j.acn.2007.11.005. Epub 2008 Feb 21.
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Gait velocity and the Timed-Up-and-Go test were sensitive to changes in mobility in frail elderly patients.步速和计时起立行走测试对体弱老年患者的活动能力变化较为敏感。
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G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.G*Power 3：一款适用于社会科学、行为科学和生物医学科学的灵活的统计功效分析程序。
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The role of higher-level cognitive function in gait: executive dysfunction contributes to fall risk in Alzheimer's disease.高级认知功能在步态中的作用：执行功能障碍导致阿尔茨海默病的跌倒风险。
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Lower extremity motor function and disability in mild cognitive impairment.轻度认知障碍患者的下肢运动功能与残疾情况
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Distance to achieve steady state walking speed in frail elderly persons.虚弱老年人达到稳定步行速度所需的距离。
Gait Posture. 2008 Jan;27(1):91-6. doi: 10.1016/j.gaitpost.2007.02.005. Epub 2007 Mar 23.
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Effect of divided attention on gait in subjects with and without cognitive impairment.注意力分散对有认知障碍和无认知障碍受试者步态的影响。
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Gait in ageing and associated dementias; its relationship with cognition.衰老及相关痴呆症中的步态；其与认知的关系。
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认知健康老化、轻度认知障碍和阿尔茨海默病患者的下肢功能。

Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease.

机构信息

Alzheimer's Disease Clinical and Research Program, Boston University School of Medicine, Boston, MA 02118-2526, USA.

出版信息

Arch Phys Med Rehabil. 2010 Apr;91(4):584-8. doi: 10.1016/j.apmr.2009.11.020.

DOI:10.1016/j.apmr.2009.11.020
PMID:20382291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2864645/
Abstract

OBJECTIVE

To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).

DESIGN

Descriptive study.

SETTING

University Alzheimer's disease clinical and research program.

PARTICIPANTS

Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURES

Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.

RESULTS

Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.

CONCLUSIONS

These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

摘要

目的

研究认知健康老年人、轻度认知障碍（MCI）老年人和阿尔茨海默病（AD）老年人下肢功能的差异。

设计

描述性研究。

地点

大学阿尔茨海默病临床和研究计划。

参与者

研究了 66 名老年人（平均年龄 76.7 岁）；22 名认知正常，22 名被诊断为可能的 MCI，22 名被诊断为可能的 AD。

干预措施

不适用。

主要观察指标

下肢功能通过 4 米步行测试（4MWT）、计时起立行走测试（TUG）和坐站测试（STS）进行评估。

结果

方差分析，调整协变量后，发现 MCI 和 AD 组的 4MWT 表现明显低于对照组。AD 组的 TUG 测试表现比对照组差。STS 表现无显著组间差异。

结论

这些结果表明认知障碍与老年人下肢功能之间存在关联。步行速度的评估可能有助于筛查认知障碍和跌倒风险较高的老年人。