Grabowska Agnieszka K, Riemer Angelika B
Immunotherapy and -prevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Open Virol J. 2012;6:249-56. doi: 10.2174/1874357901206010249. Epub 2012 Dec 28.
Human papillomavirus (HPV) needs to persist in squamous epithelia for a certain amount of time to complete its reproductive cycle. Therefore, the virus has evolved multiple immune evasion strategies. The interplay of these immune evasion mechanisms with the host immune system decides whether a HPV infection is cleared or becomes persistent. Clearance of HPV-induced lesions is mediated by a cellular immune response, consisting of both cytotoxic T lymphocyte and T helper cell responses. Persistent HPV infection, on the other hand, is the single most important risk factor for the development of HPV-associated premalignant lesions and HPV-driven cancers. This article reviews the immune evasion mechanisms employed by high-risk HPVs to escape host immune recognition and attack.
人乳头瘤病毒（HPV）需要在鳞状上皮中持续存在一定时间以完成其复制周期。因此，该病毒已进化出多种免疫逃逸策略。这些免疫逃逸机制与宿主免疫系统之间的相互作用决定了HPV感染是被清除还是持续存在。HPV诱导病变的清除由细胞免疫反应介导，包括细胞毒性T淋巴细胞反应和辅助性T细胞反应。另一方面，持续性HPV感染是HPV相关癌前病变和HPV驱动癌症发生的唯一最重要风险因素。本文综述了高危型HPV用于逃避宿主免疫识别和攻击的免疫逃逸机制。
