Phthisiopneumology Institute Chiril Draganiuc, Kishinev, Moldova.
PLoS One. 2013;8(1):e53731. doi: 10.1371/journal.pone.0053731. Epub 2013 Jan 16.
Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binary and 17 multiallelic (STRs) polymorphisms on the non-recombining portion of the Y chromosome in 125 Moldavian males. In addition, 53 Ukrainians from eastern Moldova and 54 Romanians from the neighboring eastern Romania were typed using the same set of markers. In Moldavians, 19 Y chromosome haplogroups were identified, the most common being I-M423 (20.8%), R-M17* (17.6%), R-M458 (12.8%), E-v13 (8.8%), R-M269* and R-M412* (both 7.2%). In Romanians, 14 haplogroups were found including I-M423 (40.7%), R-M17* (16.7%), R-M405 (7.4%), E-v13 and R-M412* (both 5.6%). In Ukrainians, 13 haplogroups were identified including R-M17 (34.0%), I-M423 (20.8%), R-M269* (9.4%), N-M178, R-M458 and R-M73 (each 5.7%). Our results show that a significant majority of the Moldavian paternal gene pool belongs to eastern/central European and Balkan/eastern Mediterranean Y lineages. Phylogenetic and AMOVA analyses based on Y-STR loci also revealed that Moldavians are close to both eastern/central European and Balkan-Carpathian populations. The data correlate well with historical accounts and geographical location of the region and thus allow to hypothesize that extant Moldavian paternal genetic lineages arose from extensive recent admixture between genetically autochthonous populations of the Balkan-Carpathian zone and neighboring Slavic groups.
摩尔多瓦拥有丰富的历史和文化遗产，这可能反映在其人口的当前基因构成中。迄今为止，尚无关于现代摩尔多瓦人种群遗传结构的综合研究。为了弥补这一空白，我们分析了 125 名摩尔多瓦男性非重组部分的 Y 染色体上的 37 个二态和 17 个多态性（STRs）。此外，还对来自摩尔多瓦东部的 53 名乌克兰人和来自邻国罗马尼亚东部的 54 名罗马尼亚人进行了相同标记的分型。在摩尔多瓦人中，确定了 19 个 Y 染色体单倍群，最常见的是 I-M423（20.8%）、R-M17*（17.6%）、R-M458（12.8%）、E-v13（8.8%）、R-M269和 R-M412（均为 7.2%）。在罗马尼亚人中，发现了 14 个单倍群，包括 I-M423（40.7%）、R-M17*（16.7%）、R-M405（7.4%）、E-v13 和 R-M412*（均为 5.6%）。在乌克兰人中，确定了 13 个单倍群，包括 R-M17（34.0%）、I-M423（20.8%）、R-M269*（9.4%）、N-M178、R-M458 和 R-M73（均为 5.7%）。我们的结果表明，摩尔多瓦父系基因库的绝大多数属于东欧/中欧和巴尔干/东地中海 Y 谱系。基于 Y-STR 位点的系统发生和 AMOVA 分析还表明，摩尔多瓦人与东欧/中欧和巴尔干-喀尔巴阡人口密切相关。这些数据与该地区的历史记载和地理位置很好地相关，因此可以假设现存的摩尔多瓦父系遗传谱系是由巴尔干-喀尔巴阡地区的遗传上本土人口与邻近的斯拉夫群体之间广泛的近期混合产生的。
