Conover P T, Roessmann U
Department of Pathology, University Hospitals of Cleveland, Ohio.
Arch Pathol Lab Med. 1990 May;114(5):535-8.
An infant with complex malformations of the central nervous system is described. The abnormalities included ependymal damage, aqueduct forking, hydrocephalus, and neuronal heterotopias; agenesis of the cerebellum, pontine, and inferior olivary neutrons; agenesis of the optic and olfactory systems and corpus callosum; and a highly unusual course of the corticospinal fibers in the spinal cord. Immunohistochemical test results showed the presence of influenza virus antigens in the brain. Possible pathogenetic mechanisms are presented.
描述了一名患有中枢神经系统复杂畸形的婴儿。异常情况包括室管膜损伤、导水管分叉、脑积水和神经元异位；小脑、脑桥和下橄榄核发育不全；视神经、嗅觉系统和胼胝体发育不全；以及脊髓中皮质脊髓纤维的高度异常走行。免疫组织化学检测结果显示大脑中存在流感病毒抗原。提出了可能的发病机制。
