[Anti-aggregatory and anticoagulant properties of oligoamines. 11. Oligoamines with two primary amine groups].
作者信息
Rehse K, Rose B, Leissring S
机构信息
Institut für Pharmazie, Freien Universität Berlin.
出版信息
Arch Pharm (Weinheim). 1990 Feb;323(2):103-8. doi: 10.1002/ardp.19903230210.
PMID:2334273
Abstract
Ten branched alpha,omega-alkanediamines with two primary amino groups have been synthesized and tested for their antiplatelet and anticoagulant effects. Seven of them inhibited the platelet aggregation induced by collagen at an IC50 ranging from 5-11 mumol/L. In concentrations up to 400 mumol/L the one stage thromboplastin time was only slightly prolonged (delta t less than 7s).
摘要
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