Zhou Yu, Liu Yu-Jie, Hou Shu-Xun
Department of Orthopaedics, the First Affiliated Hospital of General Hospital of PLA , Beijing 100048, China.
Zhongguo Gu Shang. 2012 Oct;25(10):852-5.
To investigate the effect of fresh meniscal allografts combined with osteochondral allografts transplantation for treatment of osteoarthritis.
Thirty-six rabbits were used in the experiment and were randomly divided into 3 groups: in group A, the fresh medial meniscal allografts combined with osteochondral allografts from medial tibial plateau were implanted into medial articular meniscal and medial tibial plateau osteochondral defects; in group B,the fresh medial meniscal allografts were implanted into medial meniscal allografts defects; in group C, the freezing medial meniscal allografts were implanted into medial meniscal allografts defects. General observation, histology examination and glycosaminoglycan (GAG) examination in cartilage of medial tibial plateau were performed at the 4th, 8th and 12th week after operation.
There were no significant differences in cellular counting and amount of GAG between group A and group B, but the cellular amount of group A was significantly more than that of group C at the 12th week.
Fresh meniscal allografts combined with osteochondral allografts transplantation can repair meniscal and osteochondral defects.
探讨新鲜半月板同种异体移植联合骨软骨异体移植治疗骨关节炎的效果。
36只兔用于实验，随机分为3组：A组将新鲜内侧半月板同种异体移植联合胫骨内侧平台骨软骨异体移植植入内侧关节半月板及胫骨内侧平台骨软骨缺损处；B组将新鲜内侧半月板同种异体移植植入内侧半月板缺损处；C组将冷冻内侧半月板同种异体移植植入内侧半月板缺损处。术后第4、8、12周进行大体观察、组织学检查及胫骨内侧平台软骨糖胺聚糖（GAG）检测。
A组与B组细胞计数及GAG含量差异无统计学意义，但术后12周A组细胞数量明显多于C组。
新鲜半月板同种异体移植联合骨软骨异体移植可修复半月板及骨软骨缺损。
