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[疑似中轴型脊柱关节炎一线患者的早期转诊:RADAR研究的比利时结果]

[Early referral of first line patients suspected of axial spondyloarthritis: the Belgian results of the RADAR study].

作者信息

Bentin J, Van Praet L, Malaise M, François D, Mielants H

机构信息

Service de Rhumatologie, CHU Brugmann, Bruxelles, Belgique.

出版信息

Rev Med Liege. 2012 Dec;67(12):649-54.

Abstract

Currently, there is a 5 to 7 years gap between the first symptoms and the diagnosis of ankylosing spondylitis. A better patient referral might reduce this gap and accelerate the adequate treatment implementation. The study objective was to compare 2 referral strategies used in first line. In Belgium, 208 referral physicians assigned to 16 rheumatology centres were randomized to refer chronic back pain patients (with onset <45 years) using 1 of the 2 referral strategies: Strategy 1 :1 of 3 criteria (inflammatory back pain, HLA-B27, sacroiliitis on imaging); or Strategy 2: 2 of6 criteria (IBP inflammatory back pain, HLA-B27, sacroiliitis, family history, good response to NSAIDs, extra-articular manifestations). Among the 141 referred patients with strategy 1 and 2, 26.0 and 36.9% respectively were diagnosed with Axial Spondylarthritis (SpA). Inflammatory back pain, sacroiliitis and good respond to NSAIDs were the most frequently used criteria (92.9 %, 36.2 % and 33.3% respectively). This study emphasizes the high prevalence of undiagnosed axial SpA in patients with chronic back pain and stressed the necessity to increase awareness of the disease.

摘要

目前,强直性脊柱炎从出现首发症状到确诊之间存在5至7年的间隔。更好的患者转诊可能会缩短这一间隔,并加速适当治疗方案的实施。本研究的目的是比较一线使用的两种转诊策略。在比利时,分配到16个风湿病中心的208名转诊医生被随机分为两组,分别采用以下两种转诊策略之一,将慢性背痛患者(发病年龄<45岁)转诊出去:策略1:三项标准中的一项(炎性背痛、HLA-B27、影像学显示的骶髂关节炎);或策略2:六项标准中的两项(炎性背痛、HLA-B27、骶髂关节炎、家族史、对非甾体抗炎药反应良好、关节外表现)。在采用策略1和策略2转诊的141例患者中,分别有26.0%和36.9%被诊断为轴性脊柱关节炎(SpA)。炎性背痛、骶髂关节炎和对非甾体抗炎药反应良好是最常使用的标准(分别为92.9%、36.2%和33.3%)。本研究强调了慢性背痛患者中未确诊的轴性SpA的高患病率,并强调了提高对该疾病认识的必要性。

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