Division of Neonatology, Ankara University School of Medicine Children's Hospital, Ankara, Turkey.
Ren Fail. 2013;35(3):411-3. doi: 10.3109/0886022X.2012.761084. Epub 2013 Jan 24.
Acquired Bartter-like syndrome (BLS), characterized by hypokalemic metabolic alkalosis, hypomagnesemia, hypocalcemia, and normal kidney function, can be induced by diuretics or antibiotics. It is a very rare condition and only anecdotal cases mostly in adults were reported. Although tubulopathy associated with colistin was reported in adults, to the best of our knowledge, colistin-associated BLS neither in adults nor in children has been reported in the literature. We here report a-28-week, 740 g female preterm infant who developed BLS just after colistin treatment for Acinetobacter baumannii infection and recovered few days after the drug cessation, and discuss the possible association of colistin and tubulopathy. More research on colistin pharmacokinetics and pharmacodynamics in critically ill patients and preterm infants is needed to guide adequate colistin dosing at the least toxicity.
获得性巴特综合征（BLS），其特征为低钾性代谢性碱中毒、低镁血症、低钙血症和正常肾功能，可由利尿剂或抗生素诱发。它是一种非常罕见的病症，仅在成人中报道了少数偶发病例。虽然已有报道称黏菌素相关的管状病变发生在成人中，但据我们所知，黏菌素相关性 BLS 无论是在成人还是儿童中，在文献中均无报道。我们在此报告一例在因感染鲍氏不动杆菌而接受黏菌素治疗后 28 周、体重 740 克的女性早产儿发生 BLS 的病例，在停止药物治疗数天后恢复，讨论黏菌素与管状病变之间可能存在的关联。需要更多关于危重症患者和早产儿中黏菌素药代动力学和药效学的研究，以指导在最小毒性下进行适当的黏菌素剂量。
