Boston Children’s Hospital, Boston, Massachusetts,USA.
Emerg Infect Dis. 2013 Feb;19(2):194-201; quiz 352. doi: 10.3201/eid1902.120039.
We describe the clinical, laboratory, and radiographic characteristics of 15 cases of eastern equine encephalitis in children during 1970-2010. The most common clinical and laboratory features were fever, headache, seizures, peripheral leukocytosis, and cerebrospinal fluid neutrophilic pleocytosis. Radiographic lesions were found in the basal ganglia, thalami, and cerebral cortex. Clinical outcomes included severe neurologic deficits in 5 (33%) patients, death of 4 (27%), full recovery of 4 (27%), and mild neurologic deficits in 2 (13%). We identify an association between a short prodrome and an increased risk for death or for severe disease.
我们描述了 1970 年至 2010 年间 15 例儿童东部马脑炎的临床、实验室和影像学特征。最常见的临床和实验室特征是发热、头痛、癫痫发作、外周白细胞增多和脑脊液中性粒细胞增多。影像学病变位于基底节、丘脑和大脑皮层。临床结局包括 5 例（33%）严重神经功能缺损、4 例（27%）死亡、4 例（27%）完全康复和 2 例（13%）轻度神经功能缺损。我们发现短潜伏期与死亡或严重疾病风险增加之间存在关联。
