Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Am J Geriatr Psychiatry. 2013 Feb;21(2):196-203. doi: 10.1016/j.jagp.2012.10.020. Epub 2013 Jan 22.
To compare lifetime prevalence of alcohol use disorder (AUD) in older adults who were hospitalized in connection with a suicide attempt and in a population comparison group, as well as to compare previous suicidal behavior in attempters with and without AUD.
Case-comparison.
Five hospitals in Western Sweden.
Persons 70 years or older, who were treated in a hospital because of a suicide attempt during 2003-2006 were recruited. Of 133 eligible participants, 103 participants were enrolled (47 men, 56 women, mean age 80 years, response rate 77%). Four comparison subjects per case were randomly selected among participants in our late-life population studies.
Lifetime history of AUD in accordance with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, was discerned on the basis of interview data, case record review, and the hospital discharge register. Depression symptoms were rated using the Montgomery-Åsberg Rating Scale.
AUD was observed in 26% of the cases and in 4% of the comparison group (odds ratio [OR]: 10.5; 95% confidence interval [CI]: 4.9-22.5). Associations were noted in men (OR: 9.5; 95% CI: 4.0-22.8) and women (OR: 12.0; 95% CI: 2.4-59.5). More than half of the cases with AUD and a third of those without AUD had made at least one prior suicide attempt. In these, AUD was associated with a longer interval between the first attempt and the index attempt.
A strong association between AUD and hospital-treated suicide attempts was noted in both sexes in this northern European setting. Given the high rates of suicide worldwide in this fast-growing and vulnerable group, comparison studies in other settings are needed.
比较因自杀未遂而住院的老年患者和人群对照组中终生酒精使用障碍(AUD)的患病率,并比较有和无 AUD 的自杀未遂者之前的自杀行为。
病例对照研究。
瑞典西部的 5 家医院。
招募了 2003-2006 年因自杀企图在医院接受治疗的 70 岁或以上的人。在 133 名符合条件的参与者中,有 103 名参与者入组(47 名男性,56 名女性,平均年龄 80 岁,应答率 77%)。每个病例随机选择我们的老年人群研究中的 4 名对照参与者。
根据访谈数据、病历回顾和医院出院登记,确定符合《精神障碍诊断与统计手册》第四版的终生 AUD 病史。使用蒙哥马利-阿斯伯格评定量表评估抑郁症状。
病例组中有 26%的人存在 AUD,而对照组中只有 4%的人存在(比值比[OR]:10.5;95%置信区间[CI]:4.9-22.5)。在男性(OR:9.5;95%CI:4.0-22.8)和女性(OR:12.0;95%CI:2.4-59.5)中均存在关联。有 AUD 的病例中超过一半,没有 AUD 的病例中有三分之一至少有一次既往自杀企图。在这些患者中,AUD 与首次尝试和索引尝试之间的时间间隔较长有关。
在北欧环境中,AUD 与在医院治疗的自杀未遂之间存在很强的关联,在两性中均如此。鉴于全世界在这个快速增长和脆弱的群体中自杀率很高,需要在其他环境中进行比较研究。