Department of Obstetrics and Gynecology, Boston University Medical Center, Boston, MA, USA.
J Low Genit Tract Dis. 2013 Apr;17(2):203-9. doi: 10.1097/LGT.0b013e3182612042.
The prevalence of cervical cancer and high-risk human papillomavirus (HPV) in Nigerian women remains poorly studied. Our objective was to estimate the prevalence of high-risk HPV and associated squamous intraepithelial lesions (SILs) in Nigeria.
After institutional review board approval, data collection was performed by volunteers of FaithCare, Inc, between 2004 and 2008 in 3 regions of Nigeria (Okene, Katari, and Abuja). Demographic data and ThinPrep Pap smears (Cytyc, Marlborough, MA) were collected from 410 women. Pap smears were analyzed for both the presence of SIL and HPV DNA.
The prevalence of high-risk HPV and SIL was 15.6% and 6.8%, respectively. Of the 28 abnormal Pap tests, 42.9% had atypical squamous cells of undetermined significance, 39.3% had low-grade SIL, 14.3% had high-grade SIL, and 3.6% had atypical glandular cells. There was a strong association between high-risk HPV and SIL in both the combined (p < .001) and individual group data (p < .001, p = .013, and p < .001 for Okene, Abuja, and Katari, respectively). However, there were no statistically significant correlations between either high-risk HPV or presence of SIL and known risk factors including age, history of sexually transmitted disease, and the number of sexual partners. There was also no statistical difference in the prevalence of high-risk HPV and SIL among the 3 locations.
A strong association exists between high-risk HPV and SIL. The prevalence of cervical high-risk HPV and SIL, however, did not vary in the 3 different locations and is consistent with reports from other regions in Africa.
尼日利亚女性的宫颈癌和高危型人乳头瘤病毒（HPV）流行情况研究甚少。本研究旨在评估尼日利亚高危型 HPV 及相关鳞状上皮内病变（SIL）的流行情况。
经机构审查委员会批准后，于 2004 年至 2008 年期间，由 FaithCare，Inc 的志愿者在尼日利亚的 3 个地区（奥凯尼、卡塔里和阿布贾）进行数据收集。共采集了 410 名女性的人口统计学数据和 ThinPrep 巴氏涂片（Cytyc，马萨诸塞州马尔伯勒）。对巴氏涂片进行 SIL 和 HPV DNA 检测。
高危型 HPV 和 SIL 的总患病率分别为 15.6%和 6.8%。在 28 例异常巴氏涂片检查中，42.9%为非典型鳞状细胞意义不明确，39.3%为低度 SIL，14.3%为高度 SIL，3.6%为非典型腺细胞。高危型 HPV 和 SIL 在合并（p<0.001）和单独组数据（p<0.001、p=0.013 和 p<0.001，分别对应奥凯尼、阿布贾和卡塔里）中均存在显著相关性。然而，高危型 HPV 和 SIL 的存在与包括年龄、性传播疾病史和性伴侣数量等已知危险因素之间均无统计学相关性。在 3 个地点之间，高危型 HPV 和 SIL 的流行率也无统计学差异。
高危型 HPV 和 SIL 之间存在显著相关性。然而，3 个不同地点的宫颈高危型 HPV 和 SIL 的流行率无差异，这与非洲其他地区的报告一致。
