Department of Urology, University of Washington School of Medicine, Seattle, WA 98195-6510, USA.
Int J Impot Res. 2013 May;25(3):109-12. doi: 10.1038/ijir.2012.48. Epub 2013 Jan 24.
Peyronie's disease (PD) is caused by progressive fibrotic scarring of the tunica albuginea resulting in curvature or other deformities of the erect penis. The severity of penile curvature or other deformity may contribute to a man's inability to have intercourse (sexual disability), due to difficulty with penetration, partner pain or emotional stress. To determine whether the degree of curvature or type of penile deformity predicts sexual disability among men with PD. This cross-sectional analysis of consecutive men evaluated for PD at a single tertiary referral center used a PD-specific questionnaire to evaluate risk factors for sexual disability in men with PD, who did not have erectile dysfunction (ED). Multivariate logistic regression was used to determine the clinical predictors of sexual disability. Sexual disability as defined by the inability to have penetrative intercourse. A total of 202 men were evaluated and 88 men with ED were excluded. Sexual disability was associated with relationship problems, penile curvature and penile length loss in bivariate, but not multivariate analysis. We found that although many of the demographic, medical and sexual function domains were significant predictors of inability to have sex, the only significant predictor of sexual disability in multivariate analysis was curvature>60° (odds ratio 3.23 95%CI 1.08-9.67). PD can be sexually disabling in many men without ED. Severe penile curvature is a robust independent predictor of the ability to have intercourse. Other penile deformities fail to predict sexual disability. This is important for counseling patients with newly diagnosed PD and those who are considering medical or surgical intervention.
佩罗尼氏病（PD）是由白膜的进行性纤维化瘢痕引起的，导致勃起阴茎的弯曲或其他畸形。阴茎弯曲的严重程度或其他畸形可能导致男性无法进行性交（性功能障碍），因为难以插入、伴侣疼痛或情绪压力。为了确定 PD 男性的弯曲程度或阴茎畸形类型是否预测性功能障碍。这是一项在单一三级转诊中心对连续男性进行的 PD 评估的横断面分析，使用 PD 特定问卷评估 PD 男性性功能障碍的危险因素，这些男性没有勃起功能障碍（ED）。使用多变量逻辑回归来确定性功能障碍的临床预测因素。性功能障碍定义为无法进行插入式性交。共评估了 202 名男性，排除了 88 名 ED 男性。性功能障碍与关系问题、阴茎弯曲和阴茎长度损失在单变量分析中相关，但在多变量分析中不相关。我们发现，尽管许多人口统计学、医学和性功能领域是无法进行性行为的重要预测因素，但多变量分析中唯一与性功能障碍相关的显著预测因素是弯曲度>60°（优势比 3.23，95%置信区间 1.08-9.67）。许多没有 ED 的 PD 男性可能会出现性功能障碍。严重的阴茎弯曲是进行性交能力的可靠独立预测因素。其他阴茎畸形不能预测性功能障碍。这对于新诊断为 PD 的患者和那些考虑药物或手术干预的患者的咨询很重要。
