Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Epidemiology. 2013 Mar;24(2):285-94. doi: 10.1097/EDE.0b013e31828174cb.
Latinos are a heterogeneous population in terms of demographics, culture, and genetic admixture from three racial groups (white, African, and Native American). This study examines the role of genetic ancestry and environmental risk factors in the risk of hypertensive disorder of pregnancy among Latinas in Los Angeles County.
Gestational hypertension, preeclampsia, eclampsia, or hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome cases (n = 125), plus unaffected controls (n = 161), were recruited from Los Angeles County + University of Southern California Women's and Children's Hospital from 1999 through 2008. Diagnoses were confirmed with extensive chart review. Personal information, demographics, and biospecimens were collected from all participants. Ancestry informative markers were used to estimate genetic ancestry proportions.
After adjusting for European ancestry and key risk factors, African ancestry was positively associated with hypertensive disorders of pregnancy risk for the highest vs. the lowest quartiles of African ancestry (odds ratio = 2.6 [95% confidence interval = 1.1-6.1]). This association was stronger among women born in Mexico with parents born in Mexico (4.3 [1.4-13]). The results from generalized additive models showed a positive association between joint European/African ancestry and hypertensive disorders of pregnancy risk and an inverse association between Native American ancestry and risk. These associations were stronger among women of Mexican origin.
Our findings suggest that higher Native American ancestry among Latinas may protect against hypertensive disorders of pregnancy. Further studies are needed to determine whether this protective effect is driven by specific alleles present in this population or by other risk factors that correlate with Native American ancestry.
拉丁裔人群在人口统计学、文化和遗传混合方面存在异质性，他们来自三个种族群体（白种人、非裔和美洲原住民）。本研究旨在探讨遗传背景和环境风险因素在洛杉矶县拉丁裔女性妊娠高血压疾病风险中的作用。
1999 年至 2008 年期间，我们从洛杉矶县南加州大学妇女儿童医院招募了妊娠高血压、子痫前期、子痫或溶血、肝酶升高和血小板减少（HELLP）综合征病例（n=125）和未受影响的对照组（n=161）。通过详细的病历回顾来确诊这些病例。所有参与者都收集了个人信息、人口统计学资料和生物样本。我们使用遗传标记来估计遗传背景的比例。
在调整了欧洲血统和关键风险因素后，与最低四分位的非洲血统相比，最高四分位的非洲血统与妊娠高血压疾病的风险呈正相关（比值比=2.6[95%置信区间 1.1-6.1]）。在父母均出生于墨西哥的墨西哥出生的女性中，这种关联更强（4.3[1.4-13]）。广义加性模型的结果显示，欧洲/非洲血统的联合与妊娠高血压疾病的风险呈正相关，而美洲原住民血统与风险呈负相关。这些关联在墨西哥裔女性中更强。
我们的研究结果表明，拉丁裔中较高的美洲原住民血统可能有助于预防妊娠高血压疾病。需要进一步的研究来确定这种保护作用是由该人群中存在的特定等位基因驱动，还是由与美洲原住民血统相关的其他风险因素驱动。
