Department of Electrical Engineering, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Sensors (Basel). 2012 Dec 21;13(1):86-105. doi: 10.3390/s130100086.
A protein concentration measurement system with two-port flexural plate-wave (FPW) biosensors using a frequency-shift readout technique is presented in this paper. The proposed frequency-shift readout method employs a peak detecting scheme to measure the amount of resonant frequency shift. The proposed system is composed of a linear frequency generator, a pair of peak detectors, two registers, and a subtractor. The frequency sweep range of the linear frequency generator is limited to 2 MHz to 10 MHz according to the characteristics of the FPW biosensors. The proposed frequency-shift readout circuit is carried out on silicon using a standard 0.18 μm CMOS technology. The sensitivity of the peak detectors is measured to be 10 mV. The power consumption of the proposed protein concentration measurement system is 48 mW given a 0.1 MHz system clock.
本文提出了一种使用频移读出技术的两端口弯曲板波（FPW）生物传感器的蛋白质浓度测量系统。所提出的频移读出方法采用峰值检测方案来测量谐振频率移的量。该系统由线性频率发生器、一对峰值检测器、两个寄存器和一个减法器组成。根据 FPW 生物传感器的特性，线性频率发生器的频率扫描范围限制在 2 MHz 到 10 MHz。所提出的频移读出电路是在硅上使用标准的 0.18μm CMOS 技术实现的。峰值检测器的灵敏度测量为 10 mV。在 0.1 MHz 系统时钟的情况下，所提出的蛋白质浓度测量系统的功耗为 48 mW。
