IEEE Trans Biomed Circuits Syst. 2020 Dec;14(6):1362-1370. doi: 10.1109/TBCAS.2020.3029912. Epub 2020 Dec 31.
This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.
本文提出了一种用于心血管疾病检查的脉冲刺激传感器读出电路。该传感器基于具有抗体后修饰的金纳米粒子板。所提出的系统利用门控脉冲来检测离子溶液中的生物标志物肌钙蛋白 I。由分析物产生的静电双层电容器的特性与溶剂中肌钙蛋白 I 的浓度有关。在晶体管感应后，电流到频率转换器（I-to-F）和基于延迟线的时间到数字转换器（TDC）将信息转换为一系列数字代码以进行进一步分析。该设计采用 0.18-μm 标准 CMOS 工艺制造。芯片占地面积为 0.92 平方毫米，功耗为 125 微瓦。在测量中，所提出的电路实现了 1.77 Hz/pg-mL 的灵敏度和 72.43 dB 的动态范围。
