Division of Plastic Surgery, Department of Surgery, Universidade Federal de São Paulo (UNIFESP), R. Bandeira Paulista 275, cj 101, 10° andar, Itaim Bibi, São Paulo, SP, CEP 04532-010, Brazil.
Aesthetic Plast Surg. 2013 Apr;37(2):434-8. doi: 10.1007/s00266-012-0048-2. Epub 2013 Jan 24.
Dark circles under or around the eyes is a cosmetic problem for a large number of people. It is a condition of unknown etiology characterized by the darkening of the eyelids and periorbital skin. The aim of this study was to determine histopathological changes associated with cutaneous idiopathic hyperchromia of the orbital region (CIHOR).
Twenty-eight adult patients with CIHOR were consecutively selected for the study. Biopsy specimens were taken from the darkened skin of the eyelid and from the normal retroauricular skin as a control.
Hemosiderin was absent in all cases. The increase in melanin content in the papillary dermis was slight in mild clinical cases and moderate in both the moderate and severe clinical cases of CIHOR. Mild dilation of blood vessels was observed in the papillary dermis at the different clinical levels of CIHOR severity, while in the reticular dermis, blood vessels showed moderate dilation and few melanophages were found.
An increase in melanin content was the most marked histological change in specimens of darkened skin. Dilation of dermal blood vessels may contribute to the severity of CIHOR. Hemosiderin was not observed in any case.
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黑眼圈或眼周色素沉着是大量人群的美容问题。它是一种病因不明的疾病，表现为眼睑和眶周皮肤变暗。本研究旨在确定与眶周皮肤特发性色素沉着（CIHOR）相关的组织病理学变化。
连续选择 28 例 CIHOR 成年患者进行研究。从变暗的眼睑皮肤和正常耳后皮肤作为对照采集活检标本。
所有病例均无含铁血黄素。在轻度临床病例中，真皮乳头层黑色素含量略有增加，在中度和重度 CIHOR 临床病例中则适度增加。在 CIHOR 严重程度的不同临床水平，真皮乳头层观察到轻度扩张的血管，而在网状真皮层，血管中度扩张，发现少量黑素细胞。
黑色素含量增加是色素沉着皮肤标本中最明显的组织学变化。真皮血管扩张可能导致 CIHOR 的严重程度增加。在任何情况下都未观察到含铁血黄素。
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