Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel, Switzerland.
Chemistry. 2013 Feb 25;19(9):3198-203. doi: 10.1002/chem.201203712. Epub 2013 Jan 23.
Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula (p-cymene)(6)Ru(6)(SR)(6)(tpt)(2) (R=CH(2)Ph, CH(2)C(6)H(4)-p-tBu, CH(2)CH(2)Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)(2)Ru(2)(SR)(2)Cl(2)], AgCF(3)SO(3) and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin-resistant cell line A2780cisR (IC(50) <0.25 μM).
具有(p-cymene)(6)Ru(6)(SR)(6)(tpt)(2) 通式的六核硫醇桥联芳烃钌金属棱柱体（R=CH(2)Ph，CH(2)C(6)H(4)-p-tBu，CH(2)CH(2)Ph；tpt=2,4,6-三（4-吡啶基）-1,3,5-三嗪），由双核前体[(p-cymene)(2)Ru(2)(SR)(2)Cl(2)]、AgCF(3)SO(3)和 tpt 得到，并作为三氟甲磺酸盐水合物分离并充分表征。这些金属棱柱体对人卵巢癌细胞具有高度的细胞毒性，特别是对顺铂耐药细胞系 A2780cisR（IC(50)<0.25 μM）。
