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前列腺癌病程中的致密性骨转移和低磷性骨软化症(作者译)

[Dense bone metastases and hypophosphatemic osteomalacia during the course of prostatic cancer (author's transl)].

作者信息

Quilichini R, Aubert L, Chauvin M, Chaffanjon P, Eisinger J

出版信息

Sem Hop. 1979;55(43-44):2037-9.

PMID:233449
Abstract

In patient bearing an advenced prostatic carcinoma with bony metastases, a major hypophosphoremia had led to the detection of an osteomalacia. As far as we know, three observations of the same syndrome have been published previously. As a pathogenic hypothesis, we propose that this tumor secret a substance which inhibit the action of vitamine D. Hypophosphoremia could result from an hyperparathyroid due to hypocalcemia.

摘要

在一名患有晚期前列腺癌并伴有骨转移的患者中,严重的低磷血症导致了骨软化症的发现。据我们所知,此前已发表过三例相同综合征的观察报告。作为一种致病假说,我们提出这种肿瘤分泌一种抑制维生素D作用的物质。低磷血症可能是由于低钙血症引起的甲状旁腺功能亢进所致。

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