Rezvani A H, Overstreet D H, Janowsky D S
Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill 27514.
Alcohol Alcohol. 1990;25(1):3-7.
Selectively bred alcohol-preferring (P) and alcohol non-preferring (NP) lines of rats were administered saline subcutaneously, and doses of 0.5 and 2.0 mg/kg of two antimuscarinic agents scopolamine (centrally acting) and methscopolamine (peripherally acting), twice daily respectively for a period of one day. Compared to saline, both doses of scopolamine and methscopolamine induced a significant reduction in ethanol consumption in the P line of rats, and both antimuscarinic agents significantly increased water intake. Thus, ethanol preference was dramatically reduced in these rats. In contrast, scopolamine had relatively little effect on either ethanol or water intake in the NP line of rats, while methscopolamine tended to suppress both ethanol and water intake. These findings suggest that peripheral muscarinic mechanisms may be involved in ethanol preference in P rats.
对选择性培育的嗜酒（P）和不嗜酒（NP）品系大鼠皮下注射生理盐水，并分别以0.5毫克/千克和2.0毫克/千克的剂量，每日两次皮下注射两种抗毒蕈碱剂东莨菪碱（中枢作用）和甲基东莨菪碱（外周作用），持续一天。与生理盐水相比，东莨菪碱和甲基东莨菪碱的两种剂量均使P品系大鼠的乙醇摄入量显著减少，且两种抗毒蕈碱剂均显著增加了水的摄入量。因此，这些大鼠的乙醇偏好显著降低。相比之下，东莨菪碱对NP品系大鼠的乙醇或水摄入量影响相对较小，而甲基东莨菪碱则倾向于抑制乙醇和水的摄入量。这些发现表明，外周毒蕈碱机制可能与P大鼠的乙醇偏好有关。
