酒精对正常及糖尿病小鼠尿糖胺聚糖和蛋白质排泄的影响。

Effect of alcohol on urinary glycosaminoglycan and protein excretion in normal and diabetic mice.

作者信息

Ramamurthi R, Leevy C B, Reddi A S

机构信息

Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103-2757.

出版信息

Alcohol Alcohol. 1990;25(1):45-50.

PMID:2334495

Abstract

The effect of alcohol on urinary glycosaminoglycan (GAG) and protein excretion was studied in one-month-old normal control C57BL/6J (CBL) and genetically diabetic (db/db) mice. Ethyl alcohol (4 g/kg) was given once a day by gavage for 58-64 days. Increased amounts of urinary total GAGs and protein were found in diabetic mice. Alcohol treatment increased urinary excretion of total GAGs, heparan sulfate and protein only in nondiabetic CBL but not in diabetic mice. Also, alcohol increased creatinine clearance only in CBL mice. The reason for the lack of effect of alcohol in diabetic mice is unknown. A significant positive linear relationship was found between urinary total GAG and protein concentrations. Possible significance of this relationship in diabetes is discussed.

摘要

在1月龄正常对照C57BL/6J（CBL）小鼠和遗传性糖尿病（db/db）小鼠中研究了酒精对尿糖胺聚糖（GAG）和蛋白质排泄的影响。通过灌胃每天给予一次乙醇（4克/千克），持续58 - 64天。在糖尿病小鼠中发现尿中总GAG和蛋白质含量增加。酒精处理仅在非糖尿病CBL小鼠中增加了尿中总GAG、硫酸乙酰肝素和蛋白质的排泄，而在糖尿病小鼠中未增加。此外，酒精仅在CBL小鼠中增加了肌酐清除率。酒精对糖尿病小鼠无作用的原因尚不清楚。发现尿中总GAG与蛋白质浓度之间存在显著的正线性关系。讨论了这种关系在糖尿病中的可能意义。