Rapin J R, Le Poncin-Lafitte M
Sem Hop. 1979;55(43-44):2047-50.
Unilateral embolization of the brain was performed in rats by intracarotid injection of 4 000 radioactive microspheres (50 mu). Local blood flow in hippocampus, striatum, hypothalamus and remainder of the brain were determined using the iodoantipyrine technique. Embolization resulted in a decreases in blood flow and modificationof the distribution of microflow. Furthermore, embolization produces changes in energy metabolism : particularly a fall in ATP and glucose levels and an increase in lactate level. Subsequently, severe vasogenic edema developed. There was a correlation between the number of microspheres injected and the amount of edema. Pretreatment using an extracted of Ginkgo biloba leaves partially suppressed the effect of embolization. An improvement of the flow in the ischemic areas associated with an improvement of the energy metabolism explain the decreases of the edema.
通过颈内动脉注射4000个放射性微球体（50微米）对大鼠进行单侧脑栓塞。采用碘安替比林技术测定海马、纹状体、下丘脑及脑的其余部分的局部血流量。栓塞导致血流量减少和微流量分布改变。此外，栓塞引起能量代谢变化：特别是三磷酸腺苷（ATP）和葡萄糖水平下降以及乳酸水平升高。随后，出现严重的血管源性水肿。注入的微球体数量与水肿量之间存在相关性。使用银杏叶提取物预处理可部分抑制栓塞的作用。缺血区域血流的改善与能量代谢的改善解释了水肿的减轻。
