纤维蛋白聚合对凝血血液流动特性的影响。
Effect of fibrin polymerzation on flow properties of coagulating blood.
作者信息
Riha P, Liao F, Stoltz J F
机构信息
Institute of Hydrodynamics, Academy of Sciences, Prague, Czech Republic.
出版信息
J Biol Phys. 1997 Jun;23(2):121-8. doi: 10.1023/A:1004973427458.
The evolution of stress in coagulating blood is described by aMaxwell-like constitutive model. The evolution is essentiallyaffected by conversion of fibrinogen to fibrin monomer, fibrinpolymerization and its crosslinking. The modifying effects of theprocess result from the active constituents of blood plasma,blood cell concentration and intensity of flow. Interrelationof stress evolution and the kinetics of polymerization species these effects in terms of the order of the kinetics ofpolymerization and degree of fibrin polymerization and values of the constitutive coefficients. The results are presented for a normal blood, averaging the effect of blood constituents and blood platelets on coagulation.
凝血过程中应力的演变由一个类似麦克斯韦的本构模型描述。这种演变主要受纤维蛋白原向纤维蛋白单体的转化、纤维蛋白聚合及其交联的影响。该过程的调节作用源于血浆中的活性成分、血细胞浓度和血流强度。应力演变与聚合动力学之间的相互关系从聚合动力学的阶数、纤维蛋白聚合程度和本构系数值方面体现了这些影响。给出了正常血液的结果，平均了血液成分和血小板对凝血的影响。
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