Tiana G, Broglia R A, Shakhnovich E I
The Niels Bohr Institute, University of Copenhagen, Bledgamsvej 16, 2100 Copenhagen, Denmark ; Department of Chemistry, Harvard University, 16 Oxford st., Cambridge, MA USA.
J Biol Phys. 2001 Jun;27(2-3):147-59. doi: 10.1023/A:1013151530254.
A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.
对模型蛋白质序列空间的能量景观进行了数值研究。由于氨基酸之间接触能量的异质性,能量景观呈现出非常粗糙的轮廓,这是受挫系统的典型行为。这导致了低能量序列的层次聚类,并可能产生进化后果。