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本文引用的文献

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Functional proteins from a random-sequence library.来自随机序列文库的功能蛋白。
Nature. 2001 Apr 5;410(6829):715-8. doi: 10.1038/35070613.
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Computational method to reduce the search space for directed protein evolution.减少定向蛋白质进化搜索空间的计算方法。
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3778-83. doi: 10.1073/pnas.051614498.
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Point mutations and sequence variability in proteins: redistributions of preexisting populations.蛋白质中的点突变和序列变异性：现有群体的重新分布。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3139-44. doi: 10.1073/pnas.051399098.
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Anatomy of protein structures: visualizing how a one-dimensional protein chain folds into a three-dimensional shape.蛋白质结构剖析：可视化一维蛋白质链如何折叠成三维形状。
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Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin.
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Experiment and theory highlight role of native state topology in SH3 folding.实验与理论凸显了天然态拓扑结构在SH3折叠中的作用。
Nat Struct Biol. 1999 Nov;6(11):1016-24. doi: 10.1038/14901.
8
The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved.SH3结构域之间的折叠过渡态在构象上受到限制且在进化上保守。
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9
The evolutionary landscape of functional model proteins.功能模型蛋白的进化图景。
Protein Eng. 1999 Sep;12(9):721-6. doi: 10.1093/protein/12.9.721.
10
Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.构建进化景观模型：序列空间中的突变稳定性、拓扑结构及超级漏斗
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10689-94. doi: 10.1073/pnas.96.19.10689.

肽链构象空间与序列空间之间的相关性。

Correlation between the conformation space and the sequence space of Peptide chain.

作者信息

Sasaki T N, Sasai M

机构信息

Graduate School of Human Informatics, Nagoya University, Nagoya, 464-8601 Japan.

出版信息

J Biol Phys. 2002 Sep;28(3):483-92. doi: 10.1023/A:1020301714197.

DOI:10.1023/A:1020301714197
PMID:23345791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3456737/
Abstract

Effects of point mutations are investigated in a computer model ofsequence selection. In the model, sequences are selected according totheir functional ability defined by the configuration at the active site.Through such functional selection on the local configuration, sequenceswhich fold globally into a unique conformation can be selected from randomsequences. The selected sequence accepts many point mutations as neutralmutations. More structurally fluctuating sites in the chain accept alarger variety of point mutations, which shows correlation between theconformational fluctuation and the sequence fluctuation.

摘要

在序列选择的计算机模型中研究了点突变的影响。在该模型中，根据活性位点处的构型所定义的功能能力来选择序列。通过对局部构型进行这种功能选择，可以从随机序列中选择全局折叠成独特构象的序列。所选序列接受许多作为中性突变的点突变。链中结构波动较大的位点接受更多种类的点突变，这表明构象波动与序列波动之间存在相关性。