肽链构象空间与序列空间之间的相关性。
Correlation between the conformation space and the sequence space of Peptide chain.
作者信息
Sasaki T N, Sasai M
机构信息
Graduate School of Human Informatics, Nagoya University, Nagoya, 464-8601 Japan.
出版信息
J Biol Phys. 2002 Sep;28(3):483-92. doi: 10.1023/A:1020301714197.
Abstract
Effects of point mutations are investigated in a computer model ofsequence selection. In the model, sequences are selected according totheir functional ability defined by the configuration at the active site.Through such functional selection on the local configuration, sequenceswhich fold globally into a unique conformation can be selected from randomsequences. The selected sequence accepts many point mutations as neutralmutations. More structurally fluctuating sites in the chain accept alarger variety of point mutations, which shows correlation between theconformational fluctuation and the sequence fluctuation.
摘要
在序列选择的计算机模型中研究了点突变的影响。在该模型中，根据活性位点处的构型所定义的功能能力来选择序列。通过对局部构型进行这种功能选择，可以从随机序列中选择全局折叠成独特构象的序列。所选序列接受许多作为中性突变的点突变。链中结构波动较大的位点接受更多种类的点突变，这表明构象波动与序列波动之间存在相关性。
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