DNA中序列依赖性空穴演化
Sequence dependent hole evolution in DNA.
作者信息
Lakhno V D
机构信息
Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow region 142290 Russian Federation.
出版信息
J Biol Phys. 2004 Jun;30(2):123-38. doi: 10.1023/B:JOBP.0000035844.35839.60.
The paper examines thedynamical behavior of a radical cation(G(+)) generated in adouble stranded DNA for differentoligonucleotide sequences. The resonancehole tunneling through an oligonucleotidesequence is studied by the method ofnumerical integration of self-consistentquantum-mechanical equations. The holemotion is considered quantum mechanicallyand nucleotide base oscillations aretreated classically. The results obtaineddemonstrate a strong dependence of chargetransfer on the type of nucleotidesequence. The rates of the hole transferare calculated for different nucleotidesequences and compared with experimentaldata on the transfer from (G(+))to a GGG unit.
本文研究了双链DNA中不同寡核苷酸序列产生的自由基阳离子（G(+)）的动力学行为。通过自洽量子力学方程的数值积分方法研究了通过寡核苷酸序列的共振空穴隧穿。空穴运动采用量子力学方法考虑，核苷酸碱基振荡采用经典方法处理。所得结果表明电荷转移强烈依赖于核苷酸序列的类型。计算了不同核苷酸序列的空穴转移速率，并与从（G(+)）到GGG单元的转移实验数据进行了比较。
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