Horhoianu I A, Horhoianu V V, Joita D, Carstoiu M, Dorobat B
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
J Med Life. 2012 Dec 15;5(4):491-5. Epub 2012 Dec 25.
The purpose of this study is to evaluate the degree of fibroid shrinkage which well correlates with symptom regression, and thus to assess the effectiveness of the procedure.
31 patients were included in the trial after selection. All the patients were thoroughly evaluated before embolization, the following day and at a month after but also at 3 months for 10 of them. A certain protocol was followed passing through well established steps. The purpose was to discover and rule out any associated possible disease and to assess and grade the symptoms, ultrasound and angiographic aspects.
Regarding the uterus, its volume evolution registered a descending trend, the mean decrease at 30 days being of 25% (-81,6 cm³) and at 90 days of 52%(-173,15 cm³). The fibroids also decreased statistically, the mean global variation at 30 days registering a decrease of -17,66 cm³(27%) and 61% at day 90. The mean global reduction at 30 days was of 44% (-33,18 cm³) and of 62% (-60,85 cm³) at 90 days. Absence of uterine anastomoses lead to proper fibroid decrease whereas their presence diminished the chances.
The uterine and fibroid volumes registered a statistical volume decrease at 30 and 90 days in comparison with the volumes before embolization. Absence of uterine anastomoses led to proper fibroid decrease. Longer evaluation time is needed for an accurate evaluation of volume reduction degree.
本研究的目的是评估肌瘤缩小程度,其与症状缓解密切相关,从而评估该手术的有效性。
筛选后31例患者纳入试验。所有患者在栓塞前、栓塞后次日、1个月时均进行全面评估,其中10例患者在3个月时也进行了评估。遵循既定步骤执行特定方案。目的是发现并排除任何相关的可能疾病,评估症状、超声和血管造影情况并进行分级。
关于子宫,其体积变化呈下降趋势,30天时平均减少25%(-81.6立方厘米),90天时减少52%(-173.15立方厘米)。肌瘤也有统计学意义的缩小,30天时平均总体变化减少-17.66立方厘米(27%),90天时减少61%。30天时平均总体缩小为44%(-33.18立方厘米),90天时为62%(-60.85立方厘米)。子宫无吻合支会使肌瘤适当缩小,而有吻合支则会减少这种可能性。
与栓塞前的体积相比,子宫和肌瘤体积在30天和90天时出现统计学意义的缩小。子宫无吻合支会使肌瘤适当缩小。需要更长的评估时间来准确评估体积缩小程度。