binge 乙醇与肝脏：新的分子进展。
Binge ethanol and liver: new molecular developments.
机构信息
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65202, USA.
出版信息
Alcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24.
Abstract
Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.
摘要
binge 饮酒是一个令人震惊的全球健康问题。 binge（急性）乙醇（EtOH）与酒精性肝病（ALD）的病理生理学有关。来自实验动物和人类的新研究表明， binge EtOH 对肝脏的免疫、信号和表观遗传参数有深远的影响。这除了急性 EtOH 的已知代谢作用之外。 binge EtOH 改变了几种细胞成分的水平，并在慢性 EtOH 暴露的肝脏中显著放大肝损伤。这些研究强调了对 EtOH binge 作用进行分子研究的重要性，以便更好地了解 ALD，并开发控制它的治疗策略。这篇综述总结了这些最新的发展。
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