Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan.
Dev Growth Differ. 2013 Feb;55(2):270-81. doi: 10.1111/dgd.12034. Epub 2013 Jan 24.
Melanocytes are pigment-producing cells generated from neural crest cells (NCCs) that delaminate from the dorsal neural tube. The widely accepted premise that NCCs migrating along the dorsolateral pathway are the main source of melanocytes in the skin was recently challenged by the finding that Schwann cell precursors are the major cellular source of melanocytes in the skin. Still, in a wide variety of vertebrate embryos, melanocytes are exclusively derived from NCCs. In this study, we show that a NCC population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin of mice. Later, these Sox1(-) cells clearly segregate from cells that originated from Sox1(+) dorsal neuroepithelial cell-derived NCCs. The possible derivation of Sox1(-) cells from epidermal cells also strengthens their non-neuroepithelial origin.
黑素细胞是由从背神经管分离出来的神经嵴细胞（NCC）产生的色素生成细胞。最近的一项发现挑战了 NCC 沿着背外侧途径迁移是皮肤中黑素细胞主要来源的这一广泛接受的前提，即施万细胞前体是皮肤中黑素细胞的主要细胞来源。尽管如此，在各种各样的脊椎动物胚胎中，黑素细胞完全来自 NCC。在这项研究中，我们表明，一种不是来源于 Sox1(+)背神经上皮细胞而是来源于 Sox1(-)细胞的 NCC 群体，在小鼠的皮肤中分化成相当数量的黑素细胞。后来，这些 Sox1(-)细胞明显与起源于 Sox1(+)背神经上皮细胞衍生的 NCC 的细胞分离。Sox1(-)细胞可能来源于表皮细胞，这也进一步证实了它们并非神经上皮细胞的起源。
