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本文引用的文献

1
The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology.胰岛素受体/胰岛素样生长因子受体家族作为肿瘤治疗靶点。
Clin Cancer Res. 2012 Jan 1;18(1):40-50. doi: 10.1158/1078-0432.CCR-11-0998.
2
Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapy.胰岛素样生长因子依赖性增殖和三阴性乳腺癌细胞的存活：治疗意义。
Neoplasia. 2011 Jun;13(6):504-15. doi: 10.1593/neo.101590.
3
Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.去氢骆驼蓬碱通过靶向糖原合成激酶-3β/β-连环蛋白通路抑制人前列腺癌细胞增殖和迁移的作用研究
Int J Cancer. 2011 Dec 15;129(12):2916-27. doi: 10.1002/ijc.25949. Epub 2011 Apr 7.
4
Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.地榆苷通过调节 Wnt 信号通路关键成员的表达抑制乳腺癌细胞的生长。
Cancer Prev Res (Phila). 2009 Nov;2(11):942-50. doi: 10.1158/1940-6207.CAPR-08-0232. Epub 2009 Oct 27.
5
Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.地榆苷通过抑制 HTLV-1 转化的 T 细胞中生存素的表达和 STAT3 磷酸化来抑制细胞增殖。
Leuk Res. 2010 Mar;34(3):352-7. doi: 10.1016/j.leukres.2009.09.003. Epub 2009 Sep 24.
6
Unraveling insulin-like growth factor binding protein-3 actions in human disease.解析胰岛素样生长因子结合蛋白-3在人类疾病中的作用
Endocr Rev. 2009 Aug;30(5):417-37. doi: 10.1210/er.2008-0028. Epub 2009 May 28.
7
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.靶向热休克蛋白90可通过阻断辐射诱导的缺氧诱导因子-1α稳定来克服肺癌细胞的耐药性。
Cancer Res. 2009 Feb 15;69(4):1624-32. doi: 10.1158/0008-5472.CAN-08-0505. Epub 2009 Jan 27.
8
Insulin and insulin-like growth factor signalling in neoplasia.肿瘤形成中的胰岛素及胰岛素样生长因子信号传导
Nat Rev Cancer. 2008 Dec;8(12):915-28. doi: 10.1038/nrc2536.
9
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.紫穗槐中抑制NF-κB激活及相关基因表达的酚类成分。
J Nat Prod. 2008 Oct;71(10):1696-700. doi: 10.1021/np800383q. Epub 2008 Oct 8.
10
Targeting insulin and insulin-like growth factor signalling in oncology.肿瘤学中针对胰岛素和胰岛素样生长因子信号传导
Curr Opin Pharmacol. 2008 Aug;8(4):384-92. doi: 10.1016/j.coph.2008.07.004. Epub 2008 Aug 20.

去冬灵通过上调乳腺癌中 IGF 结合蛋白-3 的表达靶向 IGF 受体通路的抗肿瘤活性。

A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

机构信息

Institute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.

出版信息

Cancer Lett. 2013 May 10;332(1):102-9. doi: 10.1016/j.canlet.2013.01.022. Epub 2013 Jan 21.

DOI:10.1016/j.canlet.2013.01.022
PMID:23348700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3638119/
Abstract

In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling activation, and up-regulation of IGF-binding protein-3 (IGFBP-3) expression may be associated with deguelin-mediated antitumor effects. Our findings suggest a potential therapeutic use for deguelin in patients with triple-negative breast cancer and for those with breast cancers who are sensitive to endocrine- and HER2-targeted therapies.

摘要

在这项研究中，我们研究了去氢骆驼蓬碱在体外和体内对几种人乳腺癌细胞的抗肿瘤作用。去氢骆驼蓬碱抑制三阴性（MDA-MB-231 和 MDA-MB-468）和三阳性（MCF-7）乳腺癌细胞的活力以及锚定依赖性和非锚定依赖性集落形成，并显著减少 MCF-7 细胞异种移植肿瘤的生长。凋亡的诱导、胰岛素样生长因子-1 受体（IGF-1R）信号激活的抑制和 IGF 结合蛋白-3（IGFBP-3）表达的上调可能与去氢骆驼蓬碱介导的抗肿瘤作用有关。我们的研究结果表明，去氢骆驼蓬碱在三阴性乳腺癌患者以及对内分泌和 HER2 靶向治疗敏感的乳腺癌患者中具有潜在的治疗用途。