Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Korea.
Phytother Res. 2013 Dec;27(12):1763-9. doi: 10.1002/ptr.4929. Epub 2013 Jan 24.
Prunella vulgaris var. lilacina is widely distributed in Korea, Japan, China, and Europe, and it has been traditionally used to treat inflammation or hypertension. In the present study, we investigated the effects of the ethanolic extract of the spikes of Prunella vulgaris var. lilacina (EEPV) on dizocilpine (MK-801)-induced schizophrenia-like phenotype behaviors such as the disruption of prepulse inhibition and attention deficits in mice. We also determined the effect of EEPV on MK-801-induced alterations in phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, phospho-glycogen synthase kinase 3-β, and phosphorylated cAMP response element-binding protein levels in the cortex and hippocampus of mice. MK-801-induced prepulse inhibition deficits were ameliorated by the administration of EEPV, as shown in the acoustic startle response test. Furthermore, EEPV attenuated the MK-801-induced attention deficits in the water finding test. We also found that EEPV attenuated the increased phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, or phospho-glycogen synthase kinase 3-β levels induced by MK-801 in the cortex but not in the hippocampus. These results suggest that EEPV could be useful for treating schizophrenia because EEPV ameliorates prepulse inhibition disruption and attention deficits induced by MK-801.
夏枯草变种腺毛变种广泛分布于韩国、日本、中国和欧洲，传统上用于治疗炎症或高血压。在本研究中，我们研究了夏枯草变种腺毛变种穗提取物（EEPV）对二苯并氮卓（MK-801）诱导的类似精神分裂症表型行为的影响，如前脉冲抑制的破坏和小鼠注意力缺陷。我们还确定了 EEPV 对 MK-801 诱导的皮层和海马中磷酸化细胞外信号调节激酶、磷酸化蛋白激酶 B、磷酸化糖原合成激酶 3-β 和磷酸化 cAMP 反应元件结合蛋白水平变化的影响。在听觉惊跳反应测试中，EEPV 改善了 MK-801 诱导的前脉冲抑制缺陷。此外，EEPV 减轻了 MK-801 诱导的水发现测试中的注意力缺陷。我们还发现，EEPV 减轻了 MK-801 在皮层而非海马中诱导的磷酸化细胞外信号调节激酶、磷酸化蛋白激酶 B 或磷酸化糖原合成激酶 3-β 水平的升高。这些结果表明，EEPV 可用于治疗精神分裂症，因为 EEPV 可改善 MK-801 诱导的前脉冲抑制破坏和注意力缺陷。
