内侧前额叶和枕叶皮质之间 GABA 水平的区域差异。
Regional difference in GABA levels between medial prefrontal and occipital cortices.
机构信息
Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, MD 20892, USA.
出版信息
J Magn Reson Imaging. 2013 Sep;38(3):745-50. doi: 10.1002/jmri.24009. Epub 2013 Jan 24.
Abstract
PURPOSE
To avoid the confounding effects of variations in tissue composition this study measured regional GABA differences using two voxels with the same tissue composition.
MATERIALS AND METHODS
Eighteen healthy adult volunteers were scanned using a 3 Tesla GE clinical scanner with a J-coupling based editing sequence. Spectroscopy voxels were placed in the medial prefrontal (MPFC) and occipital cortex (OCC) with essentially the same gray and white matter fractions.
RESULTS
A 16% (P = 0.0001) significantly higher GABA to creatine ratio was found in the OCC (0.1103 ± 0.0050) compared with the MPFC (0.0953 ± 0.0041). When normalized to tissue water, GABA concentrations in the OCC were 14% higher than in the MPFC.
CONCLUSION
A difference in GABA concentration was found between the OCC and MPFC voxels in healthy subjects which is attributable to differences other than tissue composition.
摘要
目的
为了避免组织成分变化带来的混杂影响，本研究使用具有相同组织成分的两个体素来测量局部 GABA 的差异。
材料与方法
18 名健康成年志愿者使用基于 J 耦合的编辑序列的 3T GE 临床扫描仪进行扫描。波谱体素分别置于前额叶内侧（MPFC）和枕叶皮层（OCC），其灰、白质比例基本相同。
结果
OCC（0.1103±0.0050）中的 GABA 与肌酸比值比 MPFC（0.0953±0.0041）高 16%（P=0.0001），差异具有统计学意义。当与组织水归一化后，OCC 中的 GABA 浓度比 MPFC 高 14%。
结论
在健康受试者中，OCC 和 MPFC 体素之间的 GABA 浓度存在差异，这归因于除组织成分以外的其他差异。
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