Deacon R, Perry J, Lumb M, Chanarin I
MRC Clinical Research Centre, Northwick Park Hospital, Harrow, UK.
FEBS Lett. 1990 Apr 24;263(2):303-4. doi: 10.1016/0014-5793(90)81399-9.
Loss of cobalamin function produces profound changes in the metabolism of formate. There is impaired synthesis of formyltetrahydropteroylglutamate synthetase (CHO-H4PteGlu), accumulation of endogenous formate and impaired utilization of [14C]formate. There are contradictory reports on the effect of cobalamin inactivation on CHO-H4PteGlu synthetase. This study confirms a significant increase in synthetase activity following cobalamin inactivation.
钴胺素功能丧失会导致甲酸代谢发生深刻变化。甲酰四氢蝶酰谷氨酸合成酶（CHO-H4PteGlu）的合成受损，内源性甲酸积累，且[14C]甲酸的利用受损。关于钴胺素失活对CHO-H4PteGlu合成酶的影响存在相互矛盾的报道。本研究证实钴胺素失活后合成酶活性显著增加。
