定量磁共振组织学图谱显示大鼠出生后脑发育情况，可对区域生长和变异性进行评估。
A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.
机构信息
Center for In Vivo Microscopy, Department of Radiology, Box 3302 Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Neuroimage. 2013 May 1;71:196-206. doi: 10.1016/j.neuroimage.2013.01.017. Epub 2013 Jan 24.
Abstract
There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease.
摘要
人们对产后大脑发育在几种神经疾病发病机制中的作用越来越感兴趣。老鼠长期以来一直被认为是研究神经病理学和药物治疗安全性的强大模型系统。然而，在大鼠神经发育过程中发生的复杂时空变化仍有待阐明。这项工作建立了第一个发育中大鼠大脑的磁共振组织学（MRH）图谱，重点是定量分析。该图谱由 9 个时间点的每个 5 个样本组成，用 8 种不同的磁共振对比成像，并分割成 26 个具有发育定义的脑区。该图谱用于建立整个神经发育过程中形态测量变化和可变性的时间表，代表了大鼠神经发育的定量数据库，用于描述人类神经疾病的大鼠模型。
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