Department of Life Sciences, Ben Gurion University of the Negev, P.O. Box 653, Beersheva 84105, Israel.
Nat Rev Microbiol. 2013 Mar;11(3):151-6. doi: 10.1038/nrmicro2957. Epub 2013 Jan 28.
Although N-glycosylation was first reported in archaea almost 40 years ago, detailed insights into this process have become possible only recently, with the availability of complete genome sequences for almost 200 archaeal species and the development of appropriate molecular tools. As a result of these advances, recent efforts have not only succeeded in delineating the pathways involved in archaeal N-glycosylation, but also begun to reveal how such post-translational protein modification helps archaea to survive in some of the harshest environments on the planet.
虽然 N-糖基化早在 40 年前就在古菌中首次被报道，但直到最近，随着近 200 种古菌的完整基因组序列的可用以及适当的分子工具的开发，人们才对这一过程有了更详细的了解。由于这些进展，最近的努力不仅成功地描绘了参与古菌 N-糖基化的途径，而且还开始揭示这种翻译后蛋白质修饰如何帮助古菌在地球上一些最恶劣的环境中生存。
