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携带肿瘤的动物合成的可诱导型55,000道尔顿白细胞介素-2受体的mRNA水平降低。

Tumour-bearing animals synthesize a decreased level of mRNA for the inducible 55,000 MW interleukin-2 receptor.

作者信息

Holán V, Lipoldová M

机构信息

Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.

出版信息

Immunology. 1990 Apr;69(4):626-8.

PMID:2335381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385640/
Abstract

Spleen cells from mice bearing progressive growing methylcholanthrene-induced syngenic tumours were deeply hyporeactive in response to T-cell mitogens. This hyporeactivity was associated with decreased ability to synthesize mRNA for the inducible 55,000 MW interleukin-2 receptor (IL-2R). Since the expression of functional IL-2R represents one of the early and pivotal events in lymphoid-cell activation, it is suggested that the defect in effective IL-2R expression may be one of the primary factors responsible for the immunological hyporeactivity of tumour-bearing hosts.

摘要

携带甲基胆蒽诱导的进行性生长同基因肿瘤的小鼠脾脏细胞，对T细胞有丝分裂原的反应呈深度低反应性。这种低反应性与合成诱导型55,000分子量白细胞介素-2受体（IL-2R）的mRNA能力降低有关。由于功能性IL-2R的表达是淋巴细胞激活的早期关键事件之一，因此提示有效IL-2R表达缺陷可能是荷瘤宿主免疫低反应性的主要因素之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ed/1385640/6eb1aa3f596d/immunology00135-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ed/1385640/6eb1aa3f596d/immunology00135-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ed/1385640/6eb1aa3f596d/immunology00135-0135-a.jpg

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Tumour-bearing animals synthesize a decreased level of mRNA for the inducible 55,000 MW interleukin-2 receptor.携带肿瘤的动物合成的可诱导型55,000道尔顿白细胞介素-2受体的mRNA水平降低。
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本文引用的文献

1
In vitro studies on mechanism of the "eclipse" of cell-mediated immunity in mice bearing advanced tumors.荷晚期肿瘤小鼠细胞介导免疫“隐蔽期”机制的体外研究
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Defect in lectin-induced interleukin 2 production by peripheral blood lymphocytes of patients with invasive urinary bladder carcinoma.浸润性膀胱癌患者外周血淋巴细胞中凝集素诱导的白细胞介素2产生缺陷。
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The interleukin 2 receptor.白细胞介素2受体
Adv Immunol. 1988;42:165-79. doi: 10.1016/s0065-2776(08)60844-5.
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The interleukin-2 receptor, its physiology and a new approach to a selective immunosuppressive therapy by anti-interleukin-2 receptor monoclonal antibodies.白细胞介素-2受体、其生理学以及通过抗白细胞介素-2受体单克隆抗体进行选择性免疫抑制治疗的新方法。
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Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence.小鼠白细胞介素-2受体cDNA的核苷酸序列及其与人白细胞介素-2受体序列的比较。
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Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).重组白细胞介素2（rIL-2）与干扰素-γ（IFN-γ）协同作用产生活化杀伤（AK）细胞。
J Immunol. 1985 May;134(5):3124-9.
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Down-regulation of the antitumor immune response.抗肿瘤免疫反应的下调。
Adv Cancer Res. 1985;45:1-43. doi: 10.1016/s0065-230x(08)60265-1.
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Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease.桥本甲状腺炎和格雷夫斯病活化T细胞克隆中T细胞受体使用情况的分析。
J Autoimmun. 1989 Feb;2(1):1-13. doi: 10.1016/0896-8411(89)90103-0.
10
Establishment and characterization of a permanent T-cell line producing an antigen non-specific suppressor factor.产生抗原非特异性抑制因子的永久性T细胞系的建立与鉴定
Immunology. 1985 Oct;56(2):275-83.