[Intercommunication between bone and central nervous system].

The discovery that leptin regulates bone formation through the central nervous system shed light on a new regulatory system of bone metabolism, i.e., neuronal control. Of note, sympathetic nervous system and parasympathetic nervous system are intimately involved in bone remodeling separately and also in a coordinated manner. Moreover, orexigenic and anorexigenic peptides also regulate bone remodeling in various ways.