Krüger M, Zinne N, Höffler H, Zhang R, Kropivnitskaja I, Schmitto J, Ciubotaru A, Haverich A
Klinik für Herz-, Transplantations-, Thorax- und Gefäßchirurgie, Medizinische Hochschule Hannover, Deutschland.
Chirurg. 2013 Mar;84(3):208-13. doi: 10.1007/s00104-012-2444-1.
First clinical experiences with the organ care system (OCS) in lung transplantation showed that this device allows perfusion and ventilation of the lungs under practically physiological conditions. Some pulmonary pathologies necessitate ex situ operations, e.g. to avoid pneumonectomy. The objective of this work was to investigate the feasibility of ex situ pulmonary surgery within the OCS.In the first procedure a large tracheobronchial leakage was covered with a pericardial patch. The procedure was authorized by the local committee of animal welfare. In the second surgery a replacement of the distal trachea using an aortic graft was performed after removal of the heart-lung segment from a pig from the slaughterhouse. The postoperative ventilation of both lungs was free of problems. The mean pressure of the pulmonary artery remained steady during the whole experiment. The setup to prevent lung edema was basically successful.Performing thoracic surgery with the OCS is feasible; however, this approach is reserved for very special indications. Further investigations to optimize technical details of the OCS setup for this purpose are necessary.
肺移植中器官护理系统(OCS)的首次临床经验表明,该设备可在几乎生理条件下实现肺的灌注和通气。一些肺部疾病需要进行体外手术,例如避免肺切除术。这项工作的目的是研究在OCS内进行体外肺部手术的可行性。在第一个手术中,用心包补片覆盖了一个大的气管支气管漏。该手术得到了当地动物福利委员会的批准。在第二个手术中,从屠宰场的一头猪身上取出心肺段后,使用主动脉移植物替换了远端气管。双肺术后通气没有问题。在整个实验过程中,肺动脉平均压力保持稳定。预防肺水肿的设置基本成功。使用OCS进行胸外科手术是可行的;然而,这种方法仅适用于非常特殊的适应症。为此,有必要进一步研究以优化OCS设置的技术细节。