Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
Curr Diab Rep. 2013 Apr;13(2):245-51. doi: 10.1007/s11892-013-0364-1.
Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs.
肥胖是一种全身性代谢失调的状态，也是导致胰岛素抵抗性糖尿病流行的一个主要因素。通过减肥手术对肥胖进行非药物治疗可显著且几乎立即逆转胰岛素抵抗。本综述综合了文献中对此现象的证据，并讨论了潜在的代谢和神经激素机制。我们提出，营养限制降低了胰岛素反应器官对营养过载的细胞防御机制。
