Ikeda S, Ogawa H
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
J Am Acad Dermatol. 1990 May;22(5 Pt 2):909-12. doi: 10.1016/0190-9622(90)70123-y.
We report the skin manifestations and abnormalities of subacute necrotizing lymphadenitis. As far as we are aware, this is the first report of this disease in the dermatology literature. The main features of subacute necrotizing lymphadenitis are fever, a cervical lymphadenopathy, and, occasionally, a skin eruption resembling urticaria, rubella, or a drug-induced erythema. A skin biopsy specimen showed a mild lymphohistiocytic perivascular infiltrate of cells in the papillary and mid dermis and deposition of fibrinogen around the capillary vessels. Subacute necrotizing lymphadenitis responds to oral corticosteroid therapy but not to antibiotics.
我们报告了亚急性坏死性淋巴结炎的皮肤表现及异常情况。据我们所知，这是皮肤病学文献中关于该疾病的首例报告。亚急性坏死性淋巴结炎的主要特征为发热、颈部淋巴结病，偶尔还会出现类似荨麻疹、风疹或药物性红斑的皮疹。皮肤活检标本显示，在乳头层和真皮中层有轻度淋巴细胞和组织细胞血管周围浸润，且毛细血管周围有纤维蛋白原沉积。亚急性坏死性淋巴结炎对口服糖皮质激素治疗有反应，但对抗生素无反应。
