Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Biochem Soc Trans. 2013 Feb 1;41(1):56-61. doi: 10.1042/BST20120283.
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In the present review, we give a brief overview of the tools available to study protein acylation, prenylation and cholesterylation, and their application in the identification and quantification of protein lipidation in health and disease.
研究翻译后修饰，如蛋白质脂质化，是后基因组时代的一个重大挑战。近年来，化学蛋白质组学领域极大地提高了我们鉴定和定量蛋白质脂质化的能力。在本综述中，我们简要概述了研究蛋白质酰化、 prenylation 和胆固醇化的可用工具，及其在鉴定和定量健康和疾病中的蛋白质脂质化中的应用。
